Engineering Advanced Nanoparticle Empowered Diagnostics

The Thomas Lab is passionate about developing more advanced nanomaterials and biosensing systems. With these systems, we hope to facilitate better diagnosis and monitoring of disease as well as to engineer new diagnostic tools to support the manufacture of biological therapeutics to treat and prevent these diseases.

As a member of the i-sense EPSRC IRC, we seek to develop nanomaterial systems capable of empowering the next generation of point-of-need (PoN) diagnostics to unprecedented levels of performance. We aim to develop nanomaterials with increased functionality and controlled design, that enable new sensing mechanisms to be envisioned and engineered. We believe there is huge potential in evolving diagnostics designed to capitalise upon computational methods that can be provided by omnipresent technologies such as the mobile phone, to develop the next generations of PoN diagnostics with worldwide reach.

These same technologies also represent tractable routes towards supporting a future of personalised biological therapeutics. As part of the push towards ultra-scale-down manufacturing and supporting fundamental biologics research, we direct our expertise towards the development of small-scale platform analytical tools for bioprocess monitoring.

Selected Publications

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Surface enhanced Raman scattering artificial nose for high dimensionality fingerprinting

Nat Commun 11, 207 (2020) doi:10.1038/s41467-019-13615-2
Nayoung Kim, Michael R. Thomas, Mads S. Bergholt, Isaac J. Pence, Hyejeong Seong, Patrick Charchar, Nevena Todorova, Anika Nagelkerke, Alexis Belessiotis-Richards, David J. Payne, Amy Gelmi, Irene Yarovsky & Molly M. Stevens
Publisher's website BibTeX
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Platinum nanocatalyst amplification: redefining the gold standard for lateral flow immunoassays with ultrabroad dynamic range

ACS nano, 12(1): 279-288, 2017
Loynachan, Colleen N and Thomas, Michael R and Gray, Eleanor R and Richards, Daniel A and Kim, Jeongyun and Miller, Benjamin S and Brookes, Jennifer C and Agarwal, Shweta and Chudasama, Vijay and McKendry, Rachel A and others
Publisher's website BibTeX
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Taking connected mobile-health diagnostics of infectious diseases to the field

Nature, 566(7745): 467, 2019
Wood, Christopher S and Thomas, Michael R and Budd, Jobie and Mashamba-Thompson, Tivani P and Herbst, Kobus and Pillay, Deenan and Peeling, Rosanna W and Johnson, Anne M and McKendry, Rachel A and Stevens, Molly M
Publisher's website BibTeX
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Nematic Director-Induced Switching of Assemblies of Hexagonally Packed Gold Nanorods

Advanced Materials, 24(32): 4424-4429, 2012
Thomas, Michael R and Klein, Susanne and Greasty, Robert J and Mann, Stephen and Perriman, Adam W and Richardson, Robert M
Publisher's website BibTeX
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Self-assembled 2D free-standing Janus nanosheets with single-layer thickness

Journal of the American Chemical Society, 139(39): 13592-13595, 2017
Lin, Yiyang and Thomas, Michael R and Gelmi, Amy and Leonardo, Vincent and Pashuck, E Thomas and Maynard, Stephanie A and Wang, Ye and Stevens, Molly M
Publisher's website BibTeX