Engineering Advanced Nanoparticle Empowered Diagnostics
The Thomas Lab is passionate about developing more advanced nanomaterials and biosensing systems. With these systems, we hope to facilitate better diagnosis and monitoring of disease as well as to engineer new diagnostic tools to support the manufacture of biological therapeutics to treat and prevent these diseases.
As a member of the i-sense EPSRC IRC, we seek to develop nanomaterial systems capable of empowering the next generation of point-of-need (PoN) diagnostics. We aim to develop nanomaterials with increased functionality through controlled design, that enable new sensing mechanisms to be envisioned and engineered. We believe there is huge potential in engineering diagnostics that can benefit from low-cost mobile phone technologies, to enable the next generations of scalable, cheap and easily performed PoN diagnostics for both resource-rich and resource limited settings.
These same technologies also represent tractable routes towards supporting a future of personalised biological therapeutics. As part of the push towards ultra-scale-down manufacturing and supporting fundamental biologics research, we direct our expertise towards the development of small-scale platform analytical tools for bioprocess monitoring and identify how analytical tools impact both treatment and testing.
Nayoung Kim, Michael R. Thomas, Mads S. Bergholt, Isaac J. Pence, Hyejeong Seong, Patrick Charchar, Nevena Todorova, Anika Nagelkerke, Alexis Belessiotis-Richards, David J. Payne, Amy Gelmi, Irene Yarovsky & Molly M. Stevens
Platinum nanocatalyst amplification: redefining the gold standard for lateral flow immunoassays with ultrabroad dynamic range
Loynachan, Colleen N and Thomas, Michael R and Gray, Eleanor R and Richards, Daniel A and Kim, Jeongyun and Miller, Benjamin S and Brookes, Jennifer C and Agarwal, Shweta and Chudasama, Vijay and McKendry, Rachel A and others