Advanced Raman spectroscopy of bioreactor production processes to develop enhanced feedback control strategies (Oct 2020)

Dr. Stephen Goldrick (UCL Biochemical Engineering) Dr. Chris Spencer (AstraZeneca, Cambridge) Dr. Michael Thomas (UCL London Centre for Nanotechnology / Biochemical Engineering) Project Description Background: Metabolic profiling of mammalian cultures enables a greater understanding of the physiological state of cells throughout a bioreactor run in addition to monitoring the key metabolite concentrations. This information is […]

  • January 20, 2020

Engineering an HIV Synthetic Biology Sensor (HIVSynse) Start Oct 2020

Lead supervisor: Dr M. Thomas (University College London) Co-supervisor: Dr S. Frank¬†(University College London) HIV is a disease affecting 40 million people worldwide, with about 85 % living in developing countries where clinical diagnostic and antiretroviral therapy monitoring platforms are limited. There is therefore a drive for cheaper, more sensitive and specific diagnostics for monitoring […]

  • January 20, 2020

PhD Position Closed: Amplification Strategies for Mobile Phone-Based Assays for Vaccine Preventable Diseases

Project Description The last 10 years have seen a number of breakthroughs in diagnostic technologies for protein biomarker detection in patient derived samples. Cutting-edge detection strategies are pushing for quantitative detection into the sub pg/mL sensitivity regime.(1) Single binding event detection technologies capable of this hold great potential in disease progression monitoring and particularly, early […]

  • December 1, 2019